Angs (Angiotensins) of the Alternative Renin-Angiotensin System Predict Outcome in Patients With Heart Failure and Preserved Ejection Fraction
نویسندگان
چکیده
منابع مشابه
Renin–Angiotensin System Inhibition, Worsening Renal Function, and Outcome in Heart Failure Patients With Reduced and Preserved Ejection Fraction
In the past 3 decades, the introduction of renin–angiotensin aldosterone system (RAAS) inhibitors has significantly improved morbidity and mortality in chronic heart failure (HF) patients with reduced ejection fraction (HFREF). Although RAAS inhibitors have beneficial effects on the heart and vasculature, they also induce a small decrease in renal function as estimated by glomerular filtration ...
متن کاملrenin-angiotensin system antagonists might reduce mortality in heart failure with preserved ejection fraction For heart failure with preserved ejection fraction (HF-
For heart failure with preserved ejection fraction (HFPEF), there is yetno evidence available of therapies reducing mortality. Three randomized clinical trials (RCTs), CHARM preserved, PEP-CHF and I-Preserve, investigated the role of renin-angiotensin system antagonists (RASA) -angiotensin II receptor blockers (ACEIs) and angiotensin II receptor blockers (ARBs) in this settingand failed to show...
متن کاملAssociation between use of renin-angiotensin system antagonists and mortality in patients with heart failure and preserved ejection fraction.
CONTEXT Heart failure with preserved ejection fraction (HFPEF) may be as common and as lethal as heart failure with reduced ejection fraction (HFREF). Three randomized trials of angiotensin-converting enzyme inhibitors or angiotensin receptor blockers (ie, renin-angiotensin system [RAS] antagonists) did not reach primary end points but may have had selection bias or been underpowered. OBJECTI...
متن کاملRenin-Angiotensin Activation and Oxidative Stress in Early Heart Failure with Preserved Ejection Fraction
Animal models have suggested a role of renin-angiotensin system (RAS) activation and subsequent cardiac oxidation in heart failure with preserved ejection fraction (HFpEF). Nevertheless, RAS blockade has failed to show efficacy in treatment of HFpEF. We evaluated the role of RAS activation and subsequent systemic oxidation in HFpEF. Oxidative stress markers were compared in 50 subjects with and...
متن کاملRenin–angiotensin blockade in heart failure with preserved ejection fraction: a systematic review and meta‐analysis
Studies with angiotensin-converting enzyme inhibitors (ACE-Is) and angiotensin receptor blockers (ARBs) in patients with heart failure with preserved ejection fraction (HFpEF) have yielded inconsistent results. To conduct a systematic review and meta-analysis of all evidence for ACE-I and ARBs in patients with HFpEF, we searched PubMed, Ovid SP, Embase, and Cochrane database to identify randomi...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Hypertension
سال: 2019
ISSN: 0194-911X,1524-4563
DOI: 10.1161/hypertensionaha.119.12786